DFP-Literaturstudium: Neurodermitis bei Jugendlichen

Die Unterbrechung des Circulus vitiosus aus Juckreiz – Kratzen – Entzündung muss das Ziel sämtlicher therapeutischer Interventionen sein. Strukturierte Patientenschulungsprogramme bewirken nicht nur eine deutliche Verbesserung der klinischen, sondern auch der psychologischen Parameter.

Beatrix Volc-Platzer*

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Literatur:

1. Margolis D et al. Persistence of mild to moderate atopic dermatitis. JAMA Dermatol 2014; 150(6):593-600
2. Silverberg JI & Hanifin JM. Adult eczema prevalence and association with asthma and other health and demographic factors: A US-population-based study. J Allergy Clin Immunol 2013; 132:1132-38
3. Mortz CG et al. Atopic dermatitis form adolescence to adulthood in the TOACS cohort: prevalence, persistence and comorbidities. Allergy 2015; 70:836-45
4. Garmhausen D et al. „Characterisation of different courses of atopic dermatitis in adolescent and adult patients.“ Allergy 2013; 68:498-506
5. Bieber T et al.“Clinical phenotypes and endotypes of atopic dermatitis: Where are we, and where should weg go?“ J Allergy Clin Immunol 2017: 139:S58-64
6. Martel BC et al. „Distinct molecular signatures of mild extrinsic and intrinsic atopic dermatitis.“ Exp Dermatol 2016; 25:453-459
7. Paternoster L et al. Multi-ancestry genome wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nature Genet 2015; 47:1449-1456
8. Scheerer C und Eyerich K. Pathogenese des atopischen Ekzems. Hautarzt 2018; 69:191-196
9. Bussmann C, Weidinger S, Novak N. Genetischer Hintergrund der atopischen Dermatitis. J Dtsch Dermatol Ges 2011; 9:670-679
10. Irvine AD, Leung DYM. Filaggrin mutations associated with skin and allergic diseases. N Engl J Med 2011; 365:1315-1327
11. Jarrett R et al. Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite-derived phospholipase. Sci Transl Med 8(325):325ra18
12. Jungersted JM et al. Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema. Allergy 2010; 65(7):911-918
13. Weidinger S & Novak N. Atopic dermatitis. Lancet 2016; 387:1109-1122
14. Misery L, Huet F, Gouin O et al. Current pharmaceutical developments in atopic dermatitis. Curr Opin Pharmacol 2019; 46:7-13
15. Reiger M, Schwierzeck V, Traidl-Hoffmann C. Atopisches Ekzem und Mikrobiom. Hautarzt 2019; 70:407-415
16. Dalgard FJ, Gieler U, Tomas-Aragones L et al. The psychological burden of skin diseases: a cross-sectional multicenter study among dermatological out-patients in 13 European countries. J Invest Dermatol 2015; 135:984-991
17. Bergmann MM et al. Evaluation of food allergy in patients with atopic dermatitis. J Allergy Clin Immunol Pract 2013; 1(1):22-28
18. Werfel T et al. S2k-Leitlinie Neurodermitis. J Dtsch Dermatol Ges 2016; 14(1):92-106
19. Pereira MP et al. Aktuelles zur Neurobiologie von Pruritus. Hautarzt 2018; 69:620-625
20. Raap U et al. IL-31 significantly correlates with disease activity and Th2 cytokine levels in children with atopic dermatitis. Ped Allergy Immunol 2012; 23:285-288
21. Wollenberg A, Barbarot S, Bieber T, Christen-Zaech S, Deleuran M, Fink-Wagner A, Gieler U, Girolomoni G, Lau S, Muraro A, Czarnecka-Operacz M, Schäfer T, Schmid-Grendelmeier P, Simon D, Szalai Z, Szepietowski JC, Taïeb A, Torrelo A, Werfel T, Ring J; European Dermatology Forum (EDF), the European Academy of Dermatology and Venereology (EADV), the European Academy of Allergy and Clinical Immunology (EAACI), the European Task Force on Atopic Dermatitis (ETFAD), European Federation of Allergy and Airways Diseases Patients’ Associations (EFA), the EuropeanSociety for Dermatology and Psychiatry (ESDaP), the European Society of Pediatric Dermatology (ESPD), Global Allergy and Asthma European Network (GA2LEN) and the European Union of Medical Specialists (UEMS). Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J Eur Acad Dermatol Venereol. 2018 May;32(5):657-682
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23. Staab D, Diepgen TL, Fartasch M, Kupfer J, Lob-Corzilius T, Ring J, Scheewe S, Scheidt R, Schmid-Ott G, Schnopp C, Szczepanski R, Werfel T, Wittenmeier M, Wahn U, Gieler U. Age related, structured educational programmes for the management of atopic dermatitis in children and adolescents: multicentre, randomised controlled trial. BMJ. 2006 Apr 22;332(7547):933-8
24. Gruber et al, Eur J Hum Genet 2007, PMID 17164798

*) ao. Univ. Prof. Dr. Dr. Beatrix Volc-Platzer, em. Vorstand der Dermatologischen Abteilung im Donauspital/SMZ Ost Wien; E-Mail: beatrix.volc-platzer@meduniwien.ac.at

Lecture Board
Priv. Doz. Dr. Maximilian Aichelburg, Facharzt für Haut- und Geschlechtskrankheiten, Wien
Priv. Doz. Dr. Robert Gruber, Universitätsklinik für Dermatologie und Venerologie, Medizinische Universität Innsbruck

Ärztlicher Fortbildungsanbieter
Österreichische Gesellschaft für Dermatologie und Venerologie (ÖGDV)

© Österreichische Ärztezeitung Nr. 13-14 / 15.07.2019